Blood cells that form the bone marrow is referred as platelets and they're containing packets of protein that's responsible for blood clotting and wound healing. As soon as the platelets are released to the bloodstream from marrow, they have circulating lifespan of approximately 7 to 10 days. You can rest assure that there's platelets accumulation at the site when there's acute injury.

There is sequence of events that take place with the formation of cloth as well as the released of growth factors. These said growth factors will attract different blood cells in the said area. Some other growth factors as well as cells are assisting with the healing process. Most of the time, addition of human thrombin and calcium chloride has been considered to be able to stimulate the release of these growth factors. There've been several counts of hypersensitivity reactions to small number of patients while bovine thrombin are used.

PRP or Platelet Rich Plasma is concentrate of the entire body containing at least 1 million platelets per 6cc's. Ideally, platelet concentration in 3 to 5 million range is ideal due to higher concentration of platelets meaning, there are more growth factors and faster healing.

It was in American Journal of Sports Medicine where one of the early papers that describe the use of PRP was established. Researchers presented non randomized study of 20 patients with chronic lateral epicondylitis or tennis elbow. For the next 2 months, the patients were closely monitored after receiving PRP treatment and there is around 60 percent improvement PRP treated group than the 16 percent in the control group. For more details about PRP, visit

This said treatment has been studied as well for Achilles tendon problems, which has produced mixed results. Dutch study was published in the journal of American Medical Association back in 2010, which involves 54 patients who showed no statistical difference between groups treated with exercise and saline and groups receiving PRP treatments. There's been some criticism with regards to studying design and other studies reporting some positive results with PRP in treating Achilles tendonitis.

Other conditions for which PRP treatment was known to be used are patellar tendonitis, rotator cuff tendonitis of shoulder, gluteus medius tendonitis of hip, plantar fasciitis and even osteoarthritis.

When the PRP is applied after needle tenotomy or a procedure to which a small incision is made to part damaged tendon by ultrasound guidance with a small needle, this create an acute injury. Truth is, this acute injury is what helps in stimulating acute inflammatory response that will cause the release of platelet's growth and healing factors as well.